The Optimization of a Polyvinyl Alcohol and Gum Tragacanth Membrane with Ciprofloxacin-Loaded Gold Nanoparticles for Wound Healing Applications

The Optimization of a Polyvinyl Alcohol and Gum Tragacanth Membrane with Ciprofloxacin-Loaded Gold Nanoparticles for Wound Healing Applications

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Bandages, gauzes, handcuff and alcoholic pads have been widely used for wound healing.However, bacterial infection in wounds is still a major problem and needs to be explored.Apart from antibacterial activity, the hydrophilicity of a membrane is also a major characteristic of membranes that should be explored.

Upon contact with wound exudates, the hydrophilic membranes absorb water, swell, and liquefy to form a gel over the wound, which enhances autolytic debridement.Keeping this in view, this study aimed to synthesize and optimize a Polyvinyl Alcohol (PVA) and Gum Tragacanth (GT) membrane having different concentrations of gold nanoparticles (AuNPs) loaded with Ciprofloxacin (CIP) and their effect on the hydrophilicity of the membranes.CIP-AuNPs were prepared by the Turkevich method, and then for confirmation FTIR was Age of the Primes performed.

Membranes with different concentrations of CIP-AuNPs incorporated in PVA/GT and analyzed for their hydrophilicity.A membrane swelling ratio test as well as contact angle analysis were performed.Through this study, it was concluded that hydrophilic membrane of PVA/GT having a 5% concentration of CIP-AuNPs can be used as a wound healing material.